Dialysate is one of the important components of blood dialysis treatment, and its composition is similar to that of the human body's internal environment, mainly consisting of four cations: sodium, potassium, magnesium, and calcium , Cl and base are two anions. The accuracy of ion concentration preparation in hemodialysis fluid directly affects the effectiveness of dialysis treatment, especially Na K. If there is a significant deviation in the concentration of Ca and Mg cations, it not only fails to achieve the expected effect of dialysis treatment, but also may cause serious clinical complications, posing a great threat to the patient's life safety. This article uses a dual channel ion chromatograph to simultaneously determine anions and cations in dialysate.